International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Invasive meningococcal disease rebound in older adults post-COVID-19 pandemic: A targeted literature and surveillance review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Yezli Saber, Bonanni Paolo, Dinleyici Ener Cagri, Divyesh Thakker, Kumar Varun, Leng Sean, Coste Florence, Taha Muhamed-Kheir
Аннотация
OBJECTIVES: Invasive meningococcal disease (IMD), caused by Neisseria meningitidis, remains a significant public health concern due to its rapid progression, high case fatality rate (CFR), and evolving epidemiology. Recent trends suggest a demographic shift toward older adults. This review examined post-COVID-19 changes in IMD epidemiology among adults aged ≥65 years, including regional variations, serogroup distribution, and mortality.
METHODS: A targeted literature review was conducted using OVID (Embase, MEDLINE) following PICOS-T criteria, including full-text English-language studies published between January 2021 and June 2024, supplemented by surveillance reports.
RESULTS: Of 1639 records screened, four peer-reviewed publications and ten surveillance reports met inclusion criteria. During the COVID-19 pandemic, IMD incidence declined sharply across all age groups, including older adults. Post-pandemic data indicate a re-emergence of IMD among older populations, with incidence in several regions returning to or exceeding pre-pandemic levels by 2023. Across multiple locations, serogroup Y emerged as the dominant or increasingly prevalent serogroup among older adults. CFR varied by region and serogroup and consistently remained high in this age group.
CONCLUSION: These findings demonstrate the re-emergence of IMD among older adults and highlight the need for strengthened IMD surveillance and serogroup monitoring in this population, to guide prevention strategies and inform public health policy.
METHODS: A targeted literature review was conducted using OVID (Embase, MEDLINE) following PICOS-T criteria, including full-text English-language studies published between January 2021 and June 2024, supplemented by surveillance reports.
RESULTS: Of 1639 records screened, four peer-reviewed publications and ten surveillance reports met inclusion criteria. During the COVID-19 pandemic, IMD incidence declined sharply across all age groups, including older adults. Post-pandemic data indicate a re-emergence of IMD among older populations, with incidence in several regions returning to or exceeding pre-pandemic levels by 2023. Across multiple locations, serogroup Y emerged as the dominant or increasingly prevalent serogroup among older adults. CFR varied by region and serogroup and consistently remained high in this age group.
CONCLUSION: These findings demonstrate the re-emergence of IMD among older adults and highlight the need for strengthened IMD surveillance and serogroup monitoring in this population, to guide prevention strategies and inform public health policy.