Science advances · 2017
An innovative biologic system for photon-powered myocardium in the ischemic heart.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Cohen Jeffrey E, Goldstone Andrew B, Paulsen Michael J, Shudo Yasuhiro, Steele Amanda N, Edwards Bryan B, Patel Jay B, MacArthur John W, Hopkins Michael S, Burnett Casey E, Jaatinen Kevin J, Thakore Akshara D, Farry Justin M, Truong Vi N, Bourdillon Alexandra T, Stapleton Lyndsay M, Eskandari Anahita, Fairman Alexander S, Hiesinger William, Esipova Tatiana V, Patrick William L, Ji Keven, Shizuru Judith A, Woo Y Joseph
Аннотация
Coronary artery disease is one of the most common causes of death and disability, afflicting more than 15 million Americans. Although pharmacological advances and revascularization techniques have decreased mortality, many survivors will eventually succumb to heart failure secondary to the residual microvascular perfusion deficit that remains after revascularization. We present a novel system that rescues the myocardium from acute ischemia, using photosynthesis through intramyocardial delivery of the cyanobacterium Synechococcus elongatus. By using light rather than blood flow as a source of energy, photosynthetic therapy increases tissue oxygenation, maintains myocardial metabolism, and yields durable improvements in cardiac function during and after induction of ischemia. By circumventing blood flow entirely to provide tissue with oxygen and nutrients, this system has the potential to create a paradigm shift in the way ischemic heart disease is treated.