Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 2026
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СтатьяКлинический случайАннотация на английскомНазвание и аннотация: Перевод в очереди
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Pasovic Lara
Аннотация
BACKGROUND: Ketamine can cause severe toxicity to both the upper and lower urinary tracts. Chronic use has been linked to ulcerative cystitis, ureteric strictures and hydronephrosis, leading to renal failure.
CASE PRESENTATION: A previously healthy woman in her thirties was admitted to hospital with severe suprapubic pain, dysuria, haematuria and urinary frequency. Imaging showed bladder wall oedema, bilateral hydronephrosis and hydroureter without obstruction. Cystoscopy revealed extensive ulcerations, granulation tissue and a markedly reduced bladder capacity (< 150 mL). Histology demonstrated denuded urothelium with necrosis and inflammation. The patient required prolonged hospitalisation for multimodal pain management and urinary diversion. After discharge, she received repeated intradetrusor botulinum toxin injections. Two years later, she disclosed heavy ketamine use prior to symptom onset and suffered recurrent acute renal failure during continued use.
INTERPRETATION: This case illustrates ketamine-induced ulcerative cystitis and renal failure. Awareness of ketamine's urological toxicity is essential in the context of increasing recreational and therapeutic use of the drug.
CASE PRESENTATION: A previously healthy woman in her thirties was admitted to hospital with severe suprapubic pain, dysuria, haematuria and urinary frequency. Imaging showed bladder wall oedema, bilateral hydronephrosis and hydroureter without obstruction. Cystoscopy revealed extensive ulcerations, granulation tissue and a markedly reduced bladder capacity (< 150 mL). Histology demonstrated denuded urothelium with necrosis and inflammation. The patient required prolonged hospitalisation for multimodal pain management and urinary diversion. After discharge, she received repeated intradetrusor botulinum toxin injections. Two years later, she disclosed heavy ketamine use prior to symptom onset and suffered recurrent acute renal failure during continued use.
INTERPRETATION: This case illustrates ketamine-induced ulcerative cystitis and renal failure. Awareness of ketamine's urological toxicity is essential in the context of increasing recreational and therapeutic use of the drug.