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Nature genetics · 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

СтатьяМетаанализПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Wuttke Matthias, Li Yong, Li Man, Sieber Karsten B, Feitosa Mary F, Gorski Mathias, Tin Adrienne, Wang Lihua, Chu Audrey Y, Hoppmann Anselm, Kirsten Holger, Giri Ayush, Chai Jin-Fang, Sveinbjornsson Gardar, Tayo Bamidele O, Nutile Teresa, Fuchsberger Christian, Marten Jonathan, Cocca Massimiliano, Ghasemi Sahar, Xu Yizhe, Horn Katrin, Noce Damia, van der Most Peter J, Sedaghat Sanaz, Yu Zhi, Akiyama Masato, Afaq Saima, Ahluwalia Tarunveer S, Almgren Peter, Amin Najaf, Ärnlöv Johan, Bakker Stephan J L, Bansal Nisha, Baptista Daniela, Bergmann Sven, Biggs Mary L, Biino Ginevra, Boehnke Michael, Boerwinkle Eric, Boissel Mathilde, Bottinger Erwin P, Boutin Thibaud S, Brenner Hermann, Brumat Marco, Burkhardt Ralph, Butterworth Adam S, Campana Eric, Campbell Archie, Campbell Harry, Canouil Mickaël, Carroll Robert J, Catamo Eulalia, Chambers John C, Chee Miao-Ling, Chee Miao-Li, Chen Xu, Cheng Ching-Yu, Cheng Yurong, Christensen Kaare, Cifkova Renata, Ciullo Marina, Concas Maria Pina, Cook James P, Coresh Josef, Corre Tanguy, Sala Cinzia Felicita, Cusi Daniele, Danesh John, Daw E Warwick, de Borst Martin H, De Grandi Alessandro, de Mutsert Renée, de Vries Aiko P J, Degenhardt Frauke, Delgado Graciela, Demirkan Ayse, Di Angelantonio Emanuele, Dittrich Katalin, Divers Jasmin, Dorajoo Rajkumar, Eckardt Kai-Uwe, Ehret Georg, Elliott Paul, Endlich Karlhans, Evans Michele K, Felix Janine F, Foo Valencia Hui Xian, Franco Oscar H, Franke Andre, Freedman Barry I, Freitag-Wolf Sandra, Friedlander Yechiel, Froguel Philippe, Gansevoort Ron T, Gao He, Gasparini Paolo, Gaziano J Michael, Giedraitis Vilmantas, Gieger Christian, Girotto Giorgia, Giulianini Franco, Gögele Martin, Gordon Scott D, Gudbjartsson Daniel F, Gudnason Vilmundur, Haller Toomas, Hamet Pavel, Harris Tamara B, Hartman Catharina A, Hayward Caroline, Hellwege Jacklyn N, Heng Chew-Kiat, Hicks Andrew A, Hofer Edith, Huang Wei, Hutri-Kähönen Nina, Hwang Shih-Jen, Ikram M Arfan, Indridason Olafur S, Ingelsson Erik, Ising Marcus, Jaddoe Vincent W V, Jakobsdottir Johanna, Jonas Jost B, Joshi Peter K, Josyula Navya Shilpa, Jung Bettina, Kähönen Mika, Kamatani Yoichiro, Kammerer Candace M, Kanai Masahiro, Kastarinen Mika, Kerr Shona M, Khor Chiea-Chuen, Kiess Wieland, Kleber Marcus E, Koenig Wolfgang, Kooner Jaspal S, Körner Antje, Kovacs Peter, Kraja Aldi T, Krajcoviechova Alena, Kramer Holly, Krämer Bernhard K, Kronenberg Florian, Kubo Michiaki, Kühnel Brigitte, Kuokkanen Mikko, Kuusisto Johanna, La Bianca Martina, Laakso Markku, Lange Leslie A, Langefeld Carl D, Lee Jeannette Jen-Mai, Lehne Benjamin, Lehtimäki Terho, Lieb Wolfgang, Lifelines Cohort Study, Lim Su-Chi, Lind Lars, Lindgren Cecilia M, Liu Jun, Liu Jianjun, Loeffler Markus, Loos Ruth J F, Lucae Susanne, Lukas Mary Ann, Lyytikäinen Leo-Pekka, Mägi Reedik, Magnusson Patrik K E, Mahajan Anubha, Martin Nicholas G, Martins Jade, März Winfried, Mascalzoni Deborah, Matsuda Koichi, Meisinger Christa, Meitinger Thomas, Melander Olle, Metspalu Andres, Mikaelsdottir Evgenia K, Milaneschi Yuri, Miliku Kozeta, Mishra Pashupati P, V. A. Million Veteran Program, Mohlke Karen L, Mononen Nina, Montgomery Grant W, Mook-Kanamori Dennis O, Mychaleckyj Josyf C, Nadkarni Girish N, Nalls Mike A, Nauck Matthias, Nikus Kjell, Ning Boting, Nolte Ilja M, Noordam Raymond, O'Connell Jeffrey, O'Donoghue Michelle L, Olafsson Isleifur, Oldehinkel Albertine J, Orho-Melander Marju, Ouwehand Willem H, Padmanabhan Sandosh, Palmer Nicholette D, Palsson Runolfur, Penninx Brenda W J H, Perls Thomas, Perola Markus, Pirastu Mario, Pirastu Nicola, Pistis Giorgio, Podgornaia Anna I, Polasek Ozren, Ponte Belen, Porteous David J, Poulain Tanja, Pramstaller Peter P, Preuss Michael H, Prins Bram P, Province Michael A, Rabelink Ton J, Raffield Laura M, Raitakari Olli T, Reilly Dermot F, Rettig Rainer, Rheinberger Myriam, Rice Kenneth M, Ridker Paul M, Rivadeneira Fernando, Rizzi Federica, Roberts David J, Robino Antonietta, Rossing Peter, Rudan Igor, Rueedi Rico, Ruggiero Daniela, Ryan Kathleen A, Saba Yasaman, Sabanayagam Charumathi, Salomaa Veikko, Salvi Erika, Saum Kai-Uwe, Schmidt Helena, Schmidt Reinhold, Schöttker Ben, Schulz Christina-Alexandra, Schupf Nicole, Shaffer Christian M, Shi Yuan, Smith Albert V, Smith Blair H, Soranzo Nicole, Spracklen Cassandra N, Strauch Konstantin, Stringham Heather M, Stumvoll Michael, Svensson Per O, Szymczak Silke, Tai E-Shyong, Tajuddin Salman M, Tan Nicholas Y Q, Taylor Kent D, Teren Andrej, Tham Yih-Chung, Thiery Joachim, Thio Chris H L, Thomsen Hauke, Thorleifsson Gudmar, Toniolo Daniela, Tönjes Anke, Tremblay Johanne, Tzoulaki Ioanna, Uitterlinden André G, Vaccargiu Simona, van Dam Rob M, van der Harst Pim, van Duijn Cornelia M, Velez Edward Digna R, Verweij Niek, Vogelezang Suzanne, Völker Uwe, Vollenweider Peter, Waeber Gerard, Waldenberger Melanie, Wallentin Lars, Wang Ya Xing, Wang Chaolong, Waterworth Dawn M, Bin Wei Wen, White Harvey, Whitfield John B, Wild Sarah H, Wilson James F, Wojczynski Mary K, Wong Charlene, Wong Tien-Yin, Xu Liang, Yang Qiong, Yasuda Masayuki, Yerges-Armstrong Laura M, Zhang Weihua, Zonderman Alan B, Rotter Jerome I, Bochud Murielle, Psaty Bruce M, Vitart Veronique, Wilson James G, Dehghan Abbas, Parsa Afshin, Chasman Daniel I, Ho Kevin, Morris Andrew P, Devuyst Olivier, Akilesh Shreeram, Pendergrass Sarah A, Sim Xueling, Böger Carsten A, Okada Yukinori, Edwards Todd L, Snieder Harold, Stefansson Kari, Hung Adriana M, Heid Iris M, Scholz Markus, Teumer Alexander, Köttgen Anna, Pattaro Cristian

Аннотация

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты