Journal of clinical ultrasound : JCU · 2026
Ultrasonographic Features of the Kidney in Patients With Frasier Syndrome and Stage 5 Chronic Kidney Disease: A Case Report and Literature Review.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Geng Wei, Li Xiaolu, Xie Yujie, Liu Jiarui, Yan Mengmeng, Li Yuchen, Ning Chunping
Аннотация
BACKGROUND: Frasier syndrome (FS) is a rare WT1-related disorder characterized by progressive nephropathy and diffuse renal parenchymal damage on imaging. Ultrasonographic findings of end-stage kidney disease in FS have rarely been documented.
METHODS: We present the case of a 12-year-old boy who was diagnosed with FS, harbored a heterozygous c.1447+5G>A mutation in his WT1 gene, and developed CKD Stage 5. Renal ultrasonography and non-contrast CT were performed. A systematic literature review was conducted to contextualize the imaging findings.
RESULTS: Non-contrast CT revealed multiple areas of abnormal density in both kidneys, which raised suspicion of Wilms tumor. Ultrasonography demonstrated multiple avascular, non-encapsulated nodular hyperechoic areas on a background of diffusely abnormal parenchyma and ruled out malignant tumors. The literature review confirmed that similar findings have rarely been reported in FS patients with CKD Stage 5.
CONCLUSION: These findings describe a distinctive end-stage renal ultrasound pattern in FS. Recognition of this pattern may help clinicians avoid unnecessary invasive procedures when renal malignancy is suspected in patients with advanced CKD.
METHODS: We present the case of a 12-year-old boy who was diagnosed with FS, harbored a heterozygous c.1447+5G>A mutation in his WT1 gene, and developed CKD Stage 5. Renal ultrasonography and non-contrast CT were performed. A systematic literature review was conducted to contextualize the imaging findings.
RESULTS: Non-contrast CT revealed multiple areas of abnormal density in both kidneys, which raised suspicion of Wilms tumor. Ultrasonography demonstrated multiple avascular, non-encapsulated nodular hyperechoic areas on a background of diffusely abnormal parenchyma and ruled out malignant tumors. The literature review confirmed that similar findings have rarely been reported in FS patients with CKD Stage 5.
CONCLUSION: These findings describe a distinctive end-stage renal ultrasound pattern in FS. Recognition of this pattern may help clinicians avoid unnecessary invasive procedures when renal malignancy is suspected in patients with advanced CKD.