Iranian journal of kidney diseases · 2018
Successful Treatment of Posttransplant Recurrent Complement C3 Glomerulopathy with Eculizumab.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Sahin Hatice, Gok Oguz Ebru, Akoglu Hadim, Atilgan Gokhan, Ulusal Okyay Gulay, Karaveli Gursoy Guner, Kip Teymur Tugba, Ertoy Dilek, Canbakan Basol, Ayli Mehmet Deniz
Аннотация
Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Nephrotic proteinuria and hematuria occurred and creatinine levels increased after transplantation. A graft biopsy revealed recurrent C3G. The patient was administered 250 mg pulse methylprednisolone for 3 days and had 9 sessions of plasmapheresis. Since elevated creatinine levels and proteinuria persisted, eculizumab was instituted. A complete remission was observed after 9-month maintenance eculizumab treatment. Eculizumab may be a potentially effective option in kidney transplant patients with recurrent C3G unresponsive to other treatment modalities.