[Bisalbuminemia: a report of three cases collected at the biochemistry laboratory of Mohammed VI University Hospital in Oujda, Morocco, and a literature review].

Bisalbuminemia is a rare qualitative anomaly characterized by the occurrence of two distinct albumin bands or a single widened albumin band on serum protein electrophoresis, reflecting the presence of a normal albumin and a modified albumin in the same individual. It can be hereditary or acquired and transient, with physiopathological mechanisms that remain poorly understood. This study presents three cases of bisalbuminemia observed at the Biochemistry Laboratory of the Mohammed VI University Hospital in Oujda. Electrophoresis results showed that all reported cases were acquired and transient. Three major causes of pseudo-bisalbuminemia were identified: administration of beta-lactam antibiotics, nephrotic syndrome, and exacerbations of chronic pancreatitis. Additionally, in light of other reported cases, we here discuss the main genetic and acquired causes of this condition.