Psychosis in Huntington's disease: A case supporting multidisciplinary and early palliative care.

Following an abrupt medication switch from olanzapine to aripiprazole, a 61-year-old female with Huntington's disease developed psychosis that persisted despite olanzapine reinstitution. Subsequent hospitalization led to significant complications, including medication adverse effects, infections (parotitis, endocarditis, cystitis), trauma in the setting of restraints, and malnutrition. This case illustrates the risk of medical and pharmacologic complications during prolonged hospitalization, diagnostic challenges in advanced HD, and the importance of multidisciplinary care with early palliative involvement.