Factors associated with subjective cognitive complaints in former American football players.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Adler Jennifer S, Ly Monica T, Yhang Eukyung, Tripodis Yorghos, Adler Charles H, Balcer Laura J, Bernick Charles, Ashton Nicholas, Zetterberg Henrik, Blennow Kaj, Peskind Elaine, Banks Sarah J, Barr William B, Wethe Jennifer V, Bondi Mark W, Delano-Wood Lisa, Cantu Robert C, Coleman Michael J, Dodick David W, Daneshvar Daniel H, McClean Michael D, Mez Jesse, Palmisano Joseph N, Martin Brett, Lin Alexander P, Koerte Inga K, Bouix Sylvain, Cummings Jeffrey L, Shenton Martha E, Reiman Eric M, Stern Robert A, Alosco Michael L, DIAGNOSE CTE Research Project
Аннотация
METHOD: Former American football players (n = 180) completed measures of global and domain-specific SCC, neuropsychiatric symptom questionnaires, neuropsychological testing, lumbar puncture, and MRI. Elastic net regression evaluated the relative importance of potential SCC correlates. Intraclass correlation coefficients measured concordance between self and informant reports. Multiple linear regressions tested associations between SCC and verbal memory and executive functioning scores. CSF Aβ1-42, p-tau181, t-tau, neurofilament light (NfL), hippocampal volume, and regional cortical thickness were examined for their potential associations with SCC.
RESULTS: Rates of SCC ranged from 43 to 77% depending on the domain. Symptoms of depression, impulsivity, and anxiety were strongly associated with SCC. Self- and informant-reported SCC showed moderate inter-rater agreement. Adjusting for age, race, education, APOE ϵ4 carrier status, and depressive symptoms, SCC were associated with lower objective verbal memory and executive functioning performance. SCC were associated with lower parahippocampal cortical thickness but not with hippocampal volume or any of the measured CSF tests.
CONCLUSIONS: SCC are strongly associated with neuropsychiatric factors in former American football players. SCC may also be a marker of cognitive decline and neurodegeneration.