Frontiers in pharmacology · 2026
Insights from real-world data: clinical features and treatment patterns of Compound Jinqiancao Granules in patients with prostatitis.
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Ma Yutong, Xiong Wenjuan, Xie Yanming
Аннотация
OBJECTIVE: To analyze the clinical characteristics and combination medication patterns of Compound Jinqiancao Granules for prostatitis in a real-world setting, and to inform the rational and safe clinical use of this preparation.
METHODS: This study comprehensively analyzed electronic medical record (EMR) data from 1,922 patients who received Compound Jinqiancao Granules. The data were extracted from the Hospital Information System (HIS) databases of 20 tertiary hospitals nationwide. Using analytical methods such as association rule mining and complex network analysis, along with algorithms like Apriori and Louvain, we systematically investigated the clinical medication characteristics and combination medication patterns.
RESULTS: Most patients were aged 46-65 years. Admissions were most frequent in the Urology Department, with the highest admission volume occurring during the Rain Water solar term. Hospital stays typically ranged from 8 to 14 days. Prostatitis was the most common primary biomedical diagnosis. Frequently combined biomedical agents included finasteride, diuretics, hemostatics, antibiotics, and glucocorticoids. Concomitant Chinese proprietary preparations followed syndrome differentiation principles: patients with Dampness-Heat Toxin Accumulation often received Compound Kushen Injection, whereas those with Qi Stagnation and Blood Stasis commonly received Yuanhu Zhitong Dropping Pills.
CONCLUSION: This study describes the real-world clinical use and medication patterns of Compound Jinqiancao Granules for prostatitis. Dosage, duration, and administration generally aligned with the drug labeling, and co-medication reflected routine clinical practice for prostatitis. Given the absence of a control group and adjustment for confounding factors, no causal inferences regarding efficacy or therapeutic effectiveness can be drawn. Keywords.
METHODS: This study comprehensively analyzed electronic medical record (EMR) data from 1,922 patients who received Compound Jinqiancao Granules. The data were extracted from the Hospital Information System (HIS) databases of 20 tertiary hospitals nationwide. Using analytical methods such as association rule mining and complex network analysis, along with algorithms like Apriori and Louvain, we systematically investigated the clinical medication characteristics and combination medication patterns.
RESULTS: Most patients were aged 46-65 years. Admissions were most frequent in the Urology Department, with the highest admission volume occurring during the Rain Water solar term. Hospital stays typically ranged from 8 to 14 days. Prostatitis was the most common primary biomedical diagnosis. Frequently combined biomedical agents included finasteride, diuretics, hemostatics, antibiotics, and glucocorticoids. Concomitant Chinese proprietary preparations followed syndrome differentiation principles: patients with Dampness-Heat Toxin Accumulation often received Compound Kushen Injection, whereas those with Qi Stagnation and Blood Stasis commonly received Yuanhu Zhitong Dropping Pills.
CONCLUSION: This study describes the real-world clinical use and medication patterns of Compound Jinqiancao Granules for prostatitis. Dosage, duration, and administration generally aligned with the drug labeling, and co-medication reflected routine clinical practice for prostatitis. Given the absence of a control group and adjustment for confounding factors, no causal inferences regarding efficacy or therapeutic effectiveness can be drawn. Keywords.