Laser Photobiomodulation of the Induratio Penis Plastica or La Peyronie's Syndrome.

Background: Since 1980, laser therapy has been proposed with success in the treatment of the Induratio Penis Plastica (IPP), also called La Peyronie's Syndrome, but still few physicians use it. Objective: We would like to investigate the clinical effects of using more laser sequentially in each session, in the treatment of chronic IPP. We used high levels of energy, watts rather than milliwatts, reducing the duration of each application, and the number of the cycles in total. Materials and methods: Laser wavelengths used for photobiomodulation (PBM) were 808, 1064, and 10,600 nm. Taking into account the clinical aspect of the lesion being treated, the specific dosage for each patient was determined. Penis echography established the exact localization and extension of the pathologic fibrous tissue as plaque, nodules, and ring. From 2012 to 2019, we treated 41 patients, 35-65 years old, who were selected using the same criteria: inflammatory signs present since ≥12 months, negative results with two other types of physical therapy, and exclusion of surgical cases. Results: Echographic test was repeated 1 month after the end of the treatment, for the evaluation of the results. Further parameters of results evaluation were presence/absence of pain, inflammation, recurvation, and functional limitation. The control was done comparing similar cases not treated with laser, selected with random criteria. Discussion and conclusions: Results were positive in a high percentage of patients, the majority after one cycle of treatment, and follow-up was positive after 2 years. The sequential use of more laser with wavelengths listed above gave better results than the wavelengths used up until the year 2000, in our previous experience. We need fewer cycles to obtain positive results, and follow-up improved significantly.