Frontiers in physiology · 2025
Comprehensive biomarker profiling reveals distinct molecular signatures across stone types: a large-scale cross-sectional study in Southern China.
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Chen Qingjiang, Huang Linliang, Wang Suilin, Wei Daqiang, Lu Jiancai, Han Xiujing, Chang Zhenglin
Аннотация
BACKGROUND: Stone diseases represent a significant global health burden affecting 10%-15% of the population worldwide. Despite advances in diagnostic imaging, current approaches often lack the ability to predict stone formation or differentiate between stone types at early stages.
METHODS: This retrospective study analyzed data from 61,310 stone patients and 55,010 matched controls using 1:1 propensity score matching. Stone cases were categorized into five major groups and further subdivided by organ system. Comprehensive serum biomarker profiling was conducted using automated biochemistry analyzers.
RESULTS: Urinary system stones constituted the largest proportion (80.97%), followed by biliary system stones (21.12%). The study revealed distinct biomarker signatures: elevated serum creatinine and cystatin C in uric acid stones; increased PSA and monocyte counts in prostatic calculi; elevated β2-microglobulin and total bilirubin in common bile duct stones; and increased basophils, ceruloplasmin, ferritin, immunoglobulin-A, and rheumatoid factor in gallstones.
CONCLUSION: This study represents the first comprehensive evaluation of stone-specific clinical biomarker patterns derived from routine laboratory parameters, providing potential diagnostic markers for different stone types and suggesting stone-specific pathophysiological mechanisms.
METHODS: This retrospective study analyzed data from 61,310 stone patients and 55,010 matched controls using 1:1 propensity score matching. Stone cases were categorized into five major groups and further subdivided by organ system. Comprehensive serum biomarker profiling was conducted using automated biochemistry analyzers.
RESULTS: Urinary system stones constituted the largest proportion (80.97%), followed by biliary system stones (21.12%). The study revealed distinct biomarker signatures: elevated serum creatinine and cystatin C in uric acid stones; increased PSA and monocyte counts in prostatic calculi; elevated β2-microglobulin and total bilirubin in common bile duct stones; and increased basophils, ceruloplasmin, ferritin, immunoglobulin-A, and rheumatoid factor in gallstones.
CONCLUSION: This study represents the first comprehensive evaluation of stone-specific clinical biomarker patterns derived from routine laboratory parameters, providing potential diagnostic markers for different stone types and suggesting stone-specific pathophysiological mechanisms.