Research progress in botany, phytochemistry, pharmacological action, toxicology, and clinical application of genus Serissa: a review.

OBJECTIVES

Serissa belongs to Rubiaceae plants, which has the effects of dispelling wind and relieving surface, clearing heat and draining dampness, relaxing the sinews, and quickening the collaterals. It has anti-inflammatory, anti-tumor, and anti-hepatitis B virus properties, inhibits bacterial growth and tyrosinase activity, and promotes coagulation and other pharmacological effects. It also has a good therapeutic effect on kidney diseases. In this paper, the botany, traditional use, processing specifications, phytochemistry, pharmacological effects, toxicology, clinical application, and quality control analysis of the genus Serissa were reviewed to provide some reference for the follow-up application of the genus Serissa.

METHODS

Literature and related information were collected from online resources such as Google Scholar, Web of Science, PubMed, CNKI, Baidu Scholar, and VIP database.

KEY FINDINGS: A total of 141 compounds were collected, including volatile oil components, flavonoids, lignans, quinones, triterpenoids, and steroids. The most important pharmacological effect of Serissa is its anti-inflammatory action, which is commonly used in the treatment of diseases such as hepatitis and nephritis.

CONCLUSION

In this paper, the botany, traditional use, processing specification, phytochemistry, pharmacological effects, toxicology, clinical application, quality control analysis, and other aspects of a comprehensive review proved that Serissa has great medicinal value.