Systemic Inflammatory Response Index in Cervical Pathologies (Human Papillomavirus and Cervical Neoplasia) and its Prognostic Value in Disease Prediction.

BACKGROUND

Cervical pathologies, from chronic cervicitis to cervical cancer, are a global public health issue. Inflammation is crucial to these disorders' development. The systemic inflammatory response may predict cancer and chronic inflammatory disease outcomes.

AIM: This study aimed to determine the importance of systemic inflammatory response indicators in human papillomavirus (HPV) infection and cervical pathologies.

METHODS

In this retrospective analysis, pap smear, HPV, cervical biopsy, complete blood count (CBC) parameters, and systemic inflammatory response index (SIRI) of women who underwent gynecological examination were evaluated.

RESULTS

The study included 452 women. Mean platelet volume (MPV) was comparable in HPV other high-risk positive and negative women but lower in HPV Type-16/18 positive women (P < 0.001). Neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, eosinophil/lymphocyte ratio (ELR), platelet/lymphocyte ratio (PLR), systemic inflammatory index [SII (platelet × neutrophil/lymphocyte)], and SIRI (neutrophil × monocyte/lymphocyte) were also similar (P > 0.05). Low-grade intraepithelial lesion (LSIL) women have lower ages and pregnancies at pap smear (P < 0.05). The high-grade intraepithelial lesion (HSIL) group showed greater platelet (PLT) counts and decreased MPV than the other groups (P < 0.05). The LSIL group had considerably reduced eosinophil counts (P < 0.05). ELR was lower in the LSIL group (P = 0.004). PLR was the highest for HSIL and lowest for LSIL (P = 0.002). The SII was highest in the HSIL group and lowest in the LSIL group (P = 0.008). PLT and MPV were lower in the cervical biopsy-classified women than in the other cervical pathology and control groups (P = 0.03 and 0.001, respectively).

CONCLUSION

We found a link between the mean PLT volume and HPV-related cervical disease.