Trazodone-Induced Ischemic Priapism Successfully Managed With Conservative Therapy: A Case Report.

Ischemic priapism is a urological emergency requiring prompt diagnosis and intervention to prevent permanent erectile dysfunction. We present the case of a 29-year-old male admitted for a painful erection lasting 10 hours. The patient had no history of trauma, hematological disease, or use of erectile medications. He had recently started trazodone (Trittico) for insomnia. Clinical examination and Doppler ultrasound confirmed low-flow priapism. Cavernosal blood gas analysis revealed severe hypoxia and acidosis. Conservative management including aspiration, irrigation, intracavernosal ephedrine, anticoagulation, and ice application led to complete detumescence without surgical intervention. The case highlights trazodone as a potential cause of ischemic priapism and the importance of early, structured management.