Open veterinary journal · 2025
Evaluation of the protective role of Malva parviflora extract in gentamicin-induced hepato-nephrotoxicity in rats.
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Mosa Amal Umran, Ubaid Moayed Mijbil, Abed Sarah Najm, Kadhim Shatha Hussein
Аннотация
BACKGROUND: Gentamicin is a widespread aminoglycoside antibiotic associated with liver and renal toxicity. To evaluate the protective role of the bioactive constituents of Malva parviflora through their antioxidant and anti-inflammatory actions.
AIM: The aim of this study was to assess the influence of M. parviflora extracton liver and renal toxicity in male albino rats after intramuscular injection of gentamicin.
METHODS: Twenty-four albino rats were partitioned arbitrarily into 4 groups: control group, gentamicin-treated group for 30 days, M. parviflora extract-treated group for 30 days, and gentamicin and Malva combined-treated group.Blood biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and oxidative stress biomarkers, malondialdehyde (MDA), glutathione (GSH), and Glutathione-S-transferase (GST), were analyzed, and histopathological alterations in the liver and kidney were evaluated. A p-value ≤ 0.05 is rated as significant statistically.
RESULTS: Significant increase in ALT, AST, and creatinine levels, and liver and renal histology examinations revealed marked alterations in gentamicin use. These alterations were attenuated by combining M. parviflora extract and preserving tissue structures and organ functions near normal. Malva parviflora reverses the oxidative stress of gentamicin by lowering the MDA concentration and recovers the GSH and GST levels seen in the group treated with gentamicin plus M. parviflora.
CONCLUSION: Gentamicin-induced renal and hepatic toxicities can be significantly reduced by M. parviflora extract and protect organs.
AIM: The aim of this study was to assess the influence of M. parviflora extracton liver and renal toxicity in male albino rats after intramuscular injection of gentamicin.
METHODS: Twenty-four albino rats were partitioned arbitrarily into 4 groups: control group, gentamicin-treated group for 30 days, M. parviflora extract-treated group for 30 days, and gentamicin and Malva combined-treated group.Blood biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and oxidative stress biomarkers, malondialdehyde (MDA), glutathione (GSH), and Glutathione-S-transferase (GST), were analyzed, and histopathological alterations in the liver and kidney were evaluated. A p-value ≤ 0.05 is rated as significant statistically.
RESULTS: Significant increase in ALT, AST, and creatinine levels, and liver and renal histology examinations revealed marked alterations in gentamicin use. These alterations were attenuated by combining M. parviflora extract and preserving tissue structures and organ functions near normal. Malva parviflora reverses the oxidative stress of gentamicin by lowering the MDA concentration and recovers the GSH and GST levels seen in the group treated with gentamicin plus M. parviflora.
CONCLUSION: Gentamicin-induced renal and hepatic toxicities can be significantly reduced by M. parviflora extract and protect organs.