Urologiia (Moscow, Russia : 1999) · 2026
[Open-label randomized comparative clinical study of the efficacy and safety of the multicomponent complex in the treatment of male infertility].
СтатьяРандомизированное исследованиеСравнительное исследованиеАннотация на английскомНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Gamidov S I, Popova A Yu, Shatylko T V, Mammaev R U, Safiullin R I, Trupakova A A
Аннотация
AIM: To evaluate the efficacy and safety of the multicomponent complex in the treatment of male infertility.
MATERIALS AND METHODS: A total of 90 patients aged 18-45 years with a confirmed diagnosis of male infertility, defined as oligozoospermia and/or asthenozoospermia were included in the study. After application of the exclusion criteria, the patients were divided into three groups. Patients in group 1 received standard lifestyle modification recommendations and the complex dietary supplement, 1 sachet once daily for 3 months; patients in group 2 received 2 sachets daily; and patients in group 3 received standard lifestyle modification recommendations only. Semen analysis was performed before enrolment and on days 30, 60, and 90. Statistical analysis was performed using IBM SPSS Statistics version 26.0.00.
RESULTS: After 90 days of therapy, significant differences between the study groups were identified in sperm motility parameters and reactive oxygen species (ROS) generation. Significant between-group differences were observed in the proportion of progressively motile spermatozoa (p=0.0037), total sperm motility (p=0.002), total progressively motile sperm count (p=0.029), total motile sperm count (p=0.0165), and ROS levels (p=0.0086). Ejaculate volume, sperm concentration, total sperm count, sperm morphology, DNA fragmentation index, and HBA test results did not differ significantly between the groups (p>0.05). Post hoc analysis showed significant differences in the proportion of motile and progressively motile spermatozoa, as well as in ROS levels, between groups 1 and 3 and between groups 2 and 3; no significant differences were observed between groups 1 and 2.
CONCLUSION: The use of the complex dietary supplement was associated with improved sperm motility parameters and reduced oxidative stress as early as during the first 1-2 months of administration, with the effect persisting through day 90.
MATERIALS AND METHODS: A total of 90 patients aged 18-45 years with a confirmed diagnosis of male infertility, defined as oligozoospermia and/or asthenozoospermia were included in the study. After application of the exclusion criteria, the patients were divided into three groups. Patients in group 1 received standard lifestyle modification recommendations and the complex dietary supplement, 1 sachet once daily for 3 months; patients in group 2 received 2 sachets daily; and patients in group 3 received standard lifestyle modification recommendations only. Semen analysis was performed before enrolment and on days 30, 60, and 90. Statistical analysis was performed using IBM SPSS Statistics version 26.0.00.
RESULTS: After 90 days of therapy, significant differences between the study groups were identified in sperm motility parameters and reactive oxygen species (ROS) generation. Significant between-group differences were observed in the proportion of progressively motile spermatozoa (p=0.0037), total sperm motility (p=0.002), total progressively motile sperm count (p=0.029), total motile sperm count (p=0.0165), and ROS levels (p=0.0086). Ejaculate volume, sperm concentration, total sperm count, sperm morphology, DNA fragmentation index, and HBA test results did not differ significantly between the groups (p>0.05). Post hoc analysis showed significant differences in the proportion of motile and progressively motile spermatozoa, as well as in ROS levels, between groups 1 and 3 and between groups 2 and 3; no significant differences were observed between groups 1 and 2.
CONCLUSION: The use of the complex dietary supplement was associated with improved sperm motility parameters and reduced oxidative stress as early as during the first 1-2 months of administration, with the effect persisting through day 90.