Biomarkers in medicine · 2026
The CALLY index: an immuno-inflammatory and nutritional index for predicting contrast induced nephropathy in patients with non-ST-elevation myocardial infarction.
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Gul Murat, Ates Muhammet Salih, Sokmen Erdogan, Inci Sinan
Аннотация
BACKGROUND: The C-reactive protein-albumin-lymphocyte (CALLY) index integrates inflammation, nutrition, and immunity. Its value for predicting contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is uncertain. We examined whether CALLY predicts CIN in non-ST-elevation myocardial infarction (NSTEMI).
METHODS: A total of 199 consecutive patients with NSTEMI who underwent PCI were retrospectively analyzed. Independent predictors were identified by multivariable logistic regression; discriminative performance was evaluated with receiver-operating characteristic (ROC) analysis.
RESULTS: CIN occurred in 32 patients (16.1%). Patients with CIN had lower CALLY values [0.49 (0.05-1.71) vs. 1.79 (0.51-4.06); p < 0.001], lower HDL-cholesterol, higher baseline creatinine, and lower estimated glomerular filtration rate. In multivariable models, CALLY independently predicted lower CIN risk (odds ratio [OR] 0.781; 95% confidence interval [CI] 0.625-0.977; p = 0.031) alongside baseline creatinine (OR 6.002; 95% CI 1.196-30.123; p = 0.029) and HDL-cholesterol (OR 0.945; 95% CI 0.900-0.993; p = 0.024). CALLY showed moderate discrimination (AUC 0.697; p < 0.001); the optimal cutoff was 1.1074 (sensitivity 61.1%, specificity 62.5%).
CONCLUSION: A lower CALLY index is independently associated with an increased risk of CIN in NSTEMI patients undergoing PCI. The CALLY index may serve as a tool for early risk stratification and targeted preventive strategies in this high-risk population.
METHODS: A total of 199 consecutive patients with NSTEMI who underwent PCI were retrospectively analyzed. Independent predictors were identified by multivariable logistic regression; discriminative performance was evaluated with receiver-operating characteristic (ROC) analysis.
RESULTS: CIN occurred in 32 patients (16.1%). Patients with CIN had lower CALLY values [0.49 (0.05-1.71) vs. 1.79 (0.51-4.06); p < 0.001], lower HDL-cholesterol, higher baseline creatinine, and lower estimated glomerular filtration rate. In multivariable models, CALLY independently predicted lower CIN risk (odds ratio [OR] 0.781; 95% confidence interval [CI] 0.625-0.977; p = 0.031) alongside baseline creatinine (OR 6.002; 95% CI 1.196-30.123; p = 0.029) and HDL-cholesterol (OR 0.945; 95% CI 0.900-0.993; p = 0.024). CALLY showed moderate discrimination (AUC 0.697; p < 0.001); the optimal cutoff was 1.1074 (sensitivity 61.1%, specificity 62.5%).
CONCLUSION: A lower CALLY index is independently associated with an increased risk of CIN in NSTEMI patients undergoing PCI. The CALLY index may serve as a tool for early risk stratification and targeted preventive strategies in this high-risk population.