Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian randomization study.

PURPOSE: We aimed to conduct a bidirectional two-sample Mendelian randomization (MR) analysis to comprehensively explore the causal associations between prostatitis and 731 immune cell properties.

METHODS

A bidirectional two-sample MR analysis was conducted to reveal their causal correlations. Sensitivity analyses were performed to assess the robustness of the results.

RESULTS

A total of 12 immune cells were found to be significantly linked with prostatitis risks, including CD39+ secreting Treg AC, B cell AC, NK %CD3- lymphocyte, CD28+ CD45RA- CD8dim %T cell, CD3 on CM CD4+ , CD3 on CD45RA- CD4+ , CD3 on CD39+ secreting Treg, CD3 on CD28+ CD4+ , CD3 on CD28+ CD45RA- CD8br, CD3 on CD28+ CD45RA+ CD8br, PDL-1 on CD14- CD16-, and CD4 on CD39+ secreting Treg (all FDRs < 0.05). Prostatitis was also found to be significantly linked with 11 immunophenotypes, containing CD25 on IgD+ CD38- unsw mem, CD38 on CD3- CD19-, CD3 on naive CD8br, CD3 on Naive CD4+ , CD3 on CD39+ CD4+ , CD3 on CD4+ , CD14 on CD14+ CD16- monocyte, CD4 on CM CD4+ , CD4 on naive CD4+ , CD4 on CD45RA+ CD4+ , and CD4 on secreting Treg (all FDRs < 0.05).

CONCLUSIONS

Our results suggest important associations between prostatitis and immune cell profiles, shedding light on the immune-related etiologies and phenotypes in prostatitis.