Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2026
Bladder to Breast Milk-DMSO Treatment of Interstitial Cystitis.
СтатьяНазвание и аннотация: Перевод в очереди
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Yamada Emily, Speck Ella, Datta Palika
Аннотация
OBJECTIVE: This study aimed to be the first to quantify dimethyl sulfoxide (DMSO) concentrations in human milk after the maternal dosing and estimate the relative infant dose (RID) to assess potential safety concerns.
METHODS: Human milk samples were obtained at different time points after the mother had received one Rimso-50 treatment. The concentrations of DMSO were then quantified at each time interval by a liquid chromatography-mass spectrometry.
RESULTS: The maximum concentration (Cmax) was observed to be 34.5 μg/mL at hour 5 post-treatment. The RID was calculated to be 0.45%, while the estimated infant dose was found to be 2 mg/kg/day.
CONCLUSION: The findings of the study demonstrate that DMSO's transfer into human milk is minimal. Additionally, the study provides the first quantification of DMSO in human milk.
METHODS: Human milk samples were obtained at different time points after the mother had received one Rimso-50 treatment. The concentrations of DMSO were then quantified at each time interval by a liquid chromatography-mass spectrometry.
RESULTS: The maximum concentration (Cmax) was observed to be 34.5 μg/mL at hour 5 post-treatment. The RID was calculated to be 0.45%, while the estimated infant dose was found to be 2 mg/kg/day.
CONCLUSION: The findings of the study demonstrate that DMSO's transfer into human milk is minimal. Additionally, the study provides the first quantification of DMSO in human milk.