Surgery today · 2026
Sex-related differences in postoperative complications after pelvic exenteration and their relationship with surgical invasiveness in a multicenter study.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kimura Kei, Igeta Masataka, Yatabe Yusuke, Fukumoto Yuko, Ito Kazuma, Imada Ayako, Song Jihyung, Kuwahara Ryuichi, Horio Yuki, Uchino Motoi, Kinugasa Yusuke, Ikeda Masataka
Аннотация
PURPOSE: To investigate the sex-related differences in postoperative complications following pelvic exenteration.
METHODS: This retrospective subanalysis used a multicenter registry of patients who underwent pelvic exenteration for locally advanced or recurrent rectal cancer. We included 218 patients (177 men and 41 women) in this study. The sex-related differences in postoperative complications were evaluated, and sex-by-factor interactions were assessed using logistic regression models, including sex, each perioperative factor, and the corresponding interaction term.
RESULTS: A significant sex-by-surgical approach interaction was observed for Clavien-Dindo Grade II or higher complications (pinteraction < 0.01). In open surgery, Grade II or higher complications occurred in 82.7% (43/52) of men compared with 38.5% (5/13) of women, whereas no clear sex difference was observed in minimally invasive surgery (69.6% [87/125] vs. 75.0% [21/28]). No significant sex-by-surgical approach interaction was detected for grade III or higher complications. Conversely, a significant sex-by-operative time interaction was observed, which was not apparent for Grade II complications.
CONCLUSION: Sex-related differences in postoperative complications after pelvic exenteration were not uniform but emerged with increased surgical invasiveness. Therefore, sex may affect the postoperative risk under conditions of increased surgical stress.
METHODS: This retrospective subanalysis used a multicenter registry of patients who underwent pelvic exenteration for locally advanced or recurrent rectal cancer. We included 218 patients (177 men and 41 women) in this study. The sex-related differences in postoperative complications were evaluated, and sex-by-factor interactions were assessed using logistic regression models, including sex, each perioperative factor, and the corresponding interaction term.
RESULTS: A significant sex-by-surgical approach interaction was observed for Clavien-Dindo Grade II or higher complications (pinteraction < 0.01). In open surgery, Grade II or higher complications occurred in 82.7% (43/52) of men compared with 38.5% (5/13) of women, whereas no clear sex difference was observed in minimally invasive surgery (69.6% [87/125] vs. 75.0% [21/28]). No significant sex-by-surgical approach interaction was detected for grade III or higher complications. Conversely, a significant sex-by-operative time interaction was observed, which was not apparent for Grade II complications.
CONCLUSION: Sex-related differences in postoperative complications after pelvic exenteration were not uniform but emerged with increased surgical invasiveness. Therefore, sex may affect the postoperative risk under conditions of increased surgical stress.