Coupling of Inflammation and Microcalcification in the Pathogenesis of Prostate Calculi: Detection Using 18 F-NaF and 18 F-FDG PET/CT.

Prostatic calculi are common and usually asymptomatic calcified stones frequently found incidentally in imaging or during the evaluation of benign prostatic hyperplasia. Those associated with chronic prostatitis can lead to bacterial colonization, inflammation, and blockage of secretory ducts, resulting in pelvic pain and lower urinary tract symptoms. Although PET tracers such as 18 F-NaF and 18 F-FDG have been used to assess metastatic and benign bone disorders, their comparative avidity in the domain of extraosseous and prostate calcification remains to be fully explored. We present incidentally detected bilateral prostatic calcification in an asymptomatic 42-year-old man exhibiting coavidity of 18 F-NaF and 18 F-FDG, highlighting the molecular coupling of inflammation and microcalcification in the pathogenesis of prostate calculi.