BMC women's health · 2026
Young women with (pre)malignant cervical disease in northern Netherlands: what characterises them - A population-based cohort study.
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Dieleman Marjolein, Vermeulen Karin M, Siebers Albert G, Wisman Bea A, Schuuring Ed, Esajas Martha D, Brandenbarg Daan, Maass Saskia W M C, de Bock Geertruida H
Аннотация
BACKGROUND: Little is known on (pre)malignant cervical disease in women below the age of population-based screening (PBS). The aim of this study was to evaluate the occurrence of (pre)malignant cervical disease and related sociodemographic characteristics in women who are tested and/or referred by the GP before reaching the eligible age (30 years) for participation in the first round of PBS for cervical cancer in the northern Netherlands.
METHODS: A linkage was performed between the Lifelines cohort (N = 88439 women) and the Dutch nationwide pathology databank (Palga). Data on cervical test records and sociodemographics such as socio-economic status and smoking status were retrieved and analysed.
RESULTS: A cervical test record before the first round of PBS was reported for 6301 women. Cervical intra-epithelial neoplasia grade 2 or higher (CIN2+) was diagnosed in 198 (3.1%) women. CIN2 + was associated with low educational level (adjusted odds ratio (aOR) 1.7, 95% confidence interval (CI) 1.1-2.4), ex-smoking (aOR 1.8, 95%CI 1.2-2.9) and current smoking (aOR 2.7, 95%CI 1.9-3.8).
CONCLUSIONS: Within women tested and/or referred by the GP before the eligible age for the Dutch cervical cancer PBS, 3.1% was diagnosed with CIN2+. Higher odds of CIN2 + for women with a low educational level and women who (used to) smoke should be taken along in clinical decision making towards testing and referral.
METHODS: A linkage was performed between the Lifelines cohort (N = 88439 women) and the Dutch nationwide pathology databank (Palga). Data on cervical test records and sociodemographics such as socio-economic status and smoking status were retrieved and analysed.
RESULTS: A cervical test record before the first round of PBS was reported for 6301 women. Cervical intra-epithelial neoplasia grade 2 or higher (CIN2+) was diagnosed in 198 (3.1%) women. CIN2 + was associated with low educational level (adjusted odds ratio (aOR) 1.7, 95% confidence interval (CI) 1.1-2.4), ex-smoking (aOR 1.8, 95%CI 1.2-2.9) and current smoking (aOR 2.7, 95%CI 1.9-3.8).
CONCLUSIONS: Within women tested and/or referred by the GP before the eligible age for the Dutch cervical cancer PBS, 3.1% was diagnosed with CIN2+. Higher odds of CIN2 + for women with a low educational level and women who (used to) smoke should be taken along in clinical decision making towards testing and referral.