Rare Coexistence of Ménétrier's Disease and Gallbladder Duplication in a Young Male Adult: A Case Report.

Background and Objectives: Ménétrier's disease (MD) is an exceptionally rare hypertrophic gastropathy characterized by foveolar hyperplasia, gastric acid suppression, and protein-losing enteropathy. Congenital gallbladder duplication is a rare biliary anomaly associated with independent pathological risks and surgical complications. Case Presentation: We report the case of a 34-year-old male presenting with chronic epigastric and right hypochondriac pain, alongside persistent, uninvestigated polycythemia. Upper endoscopy and histopathology revealed diffuse foveolar hyperplasia with cystic oxyntic gland dilatation and active Helicobacter pylori infection, confirming MD. Magnetic resonance cholangiopancreatography demonstrated a double gallbladder with independent cystic ducts. Successful H. pylori eradication was achieved, and hematological workup ruled out primary myeloproliferative neoplasm. Conclusions: To our knowledge, this is the first reported case of concurrent MD, and double gallbladder. This report underscores the necessity of a systematic diagnostic approach combining advanced imaging and histopathology to manage complex, overlapping abdominal pathologies.