Evaluation of the relationship between testosterone level in patients with urethral stricture and its effect on outcome of surgery.

PURPOSE: Assessing the association between Testosterone (T)-level in patients with urethral stricture (US) and its effect on surgery outcome.

METHODS

This prospective study includes 70 cases of developing US disease and anastomotic Urethroplasty. All patients underwent retrograde and voiding urethrography, pelvi-abdominal ultrasound, and T (free and total) measurements.

RESULTS

A significant negative association was found between free T, age, and post-void residual volume (PVR) pre. Also, a positive association between free T and Hemoglobin (Hb) levels. Besides, an association between wound infection and total T. There was a significant lower in PVR and higher in Q-max post-urethroplasty than pre-urethroplasty. International prostate symptom score (IPSS) showed a significant decrease in post-urethroplasty and at 3 months follow up than pre-urethroplasty (p < 0.05). Diabetes mellitus, free, and total T showed significant differences between the studied groups. Also, it can predict failure results respectively at cut-off ⩽123.75 and ⩽765.8 with 85.70% sensitivity, 98.40%, and 88.90% specificity.

CONCLUSIONS

Diabetic status, wound infection, and free and total T significantly affect the success rate in patients with the US, while preoperative PVR, Q-max, and IPSS did not affect the success rate.