Раннее выявление лиц, подверженных риску множественных склерозов, путем количественной оценки EBNA-1381-452, конкретно относящихся к антителам.
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Vietzen Hannes, Kühner Laura M, Berger Sarah M, Ponleitner Markus, Graninger Marianne, Pistorius Charlotte, Jungbauer Christof, Reindl Markus, Saucke Henrieke, Kauth Franziska, Wendel Eva-Maria, Rostásy Kevin, Breu Markus, Kornek Barbara, Bsteh Gabriel, Berger Thomas, Rommer Paulus, Puchhammer-Stöckl Elisabeth
Аннотация
Оригинал публикации
Early identification of individuals at risk for multiple sclerosis by quantification of EBNA-1381-452-specific antibody titers.
Multiple sclerosis (MS) is an immune-mediated demyelinating disease. Epstein-Barr virus (EBV) encodes for the EBNA-1381-452 region that induces autoreactive antibody responses, which are likely critically involved in MS pathogenesis. Here we investigate whether these EBNA-1381-452-specific antibodies can serve as a biomarker to identify at-risk individuals for MS. We quantify EBNA-1381-452-specific antibody titers from 324 relapsing-remitting MS patients and 324 matched controls in longitudinal follow-up plasma samples, starting from the individual's EBV-seroconversion. In MS patients, significantly elevated EBNA-1381-452-specific IgG titers are identified that are increased already as early as nine months after EBV-seroconversion (OR:5.7; 95% CI: 4.1-8.1; P < 0.0001) and a median 5.4 years prior to MS diagnosis. Especially, the presence of continuously high EBNA-1381-452-specific antibody titers is associated with a more rapid MS diagnosis after EBV-seroconversion (P < 0.0001). Thus, the quantification of EBNA-1381-452-specific IgG antibody levels may provide a prognostic biomarker to determine the individual's risk for the diagnosis of MS.