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DOI 10.1182/bloodadvances.2023011658

Медицинская библиотека · Blood advances · 2024

Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.

Frerichs Kristine A, Verkleij Christie P M, Mateos Maria Victoria, Martin Thomas G, Rodriguez Cesar, Nooka Ajay, Banerjee Arnob, Chastain Katherine, Perales-Puchalt Alfredo, Stephenson Tara, Uhlar Clarissa, Kobos Rachel, van der Holt Bronno, Kruyswijk Sandy, Kuipers Maria T, Groen Kaz, Vishwamitra Deeksha, Skerget Sheri, Cortes-Selva Diana, Doyle Margaret, Zaaijer Hans L, Zweegman Sonja, Verona Raluca I, van de Donk Niels W C J

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Аннотация

CONTEXT: Although the relationship between workload and injury incidence has recently gained attention, data on the acute-to-chronic workload ratio (ACWR) and injury incidence in Taekwondo remain unavailable.

OBJECTIVE

To report the injury incidence related to the categorized ACWR, calculated using the rolling average (RA) and exponentially weighted moving average (EWMA) methods, for musculoskeletal injuries in Taekwondo.

DESIGN

Descriptive epidemiologic study.

SETTING

Data were prospectively collected through Taekwondo training facilities and competition venues.

PATIENTS OR OTHER

PARTICIPANTS

A total of 110 collegiate Taekwondo players (58 females; 54 males) were studied over three consecutive seasons in 2020, 2021, and 2022.

MAIN OUTCOME MEASURES(S): The traumatic and gradual onset of musculoskeletal injury (rate, body location, type, mechanism, and severity) and workloads (duration of training and competitions) were recorded. ACWRs for each injury were calculated using the RA and EWMA and categorized as either high (> 1.5), relatively high (1.3 - 1.5), moderate (0.8 - 1.3), or low (<0.8).

RESULTS

Of the 841 injuries (training: 16 per 1,000 hours; competition: 548 per 1,000 hours), the ankle (n=86/501, 17% in traumatic) and thigh (n=106/340, 31% in gradual onset) were the most predominantly injured body locations. Contusion (n=201/501, 40% in traumatic) and muscle cramps/spasm (n=201/501, 75% in gradual onset) were the most frequent injury types. Although the most predominant mechanism was overuse (n=331/841, 40%), 32% of the injuries (n=230/721) took > 28 days to recover from injury. The greatest number of traumatic (RA: n=224/501, 45%; EWMA: n=259/501; 52%) and gradual onset (RA: n=118/340, 35%; EWMA: n=165/340; 49%) injuries were recorded under the moderate ACWR.

CONCLUSIONS

The moderate ACWR range (0.8 - 1.3), which was considered as the "sweet spot" in team sports, was calculated to be the "danger zone" in Taekwondo. The high injury risk related workload could be used for planning training schedules.

Для цитирования: Frerichs Kristine A, Verkleij Christie P M, Mateos Maria Victoria, Martin Thomas G, Rodriguez Cesar, Nooka Ajay, Banerjee Arnob, Chastain Katherine, Perales-Puchalt Alfredo, Stephenson Tara, Uhlar Clarissa, Kobos Rachel, van der Holt Bronno, Kruyswijk Sandy, Kuipers Maria T, Groen Kaz, Vishwamitra Deeksha, Skerget Sheri, Cortes-Selva Diana, Doyle Margaret, Zaaijer Hans L, Zweegman Sonja, Verona Raluca I, van de Donk Niels W C J. Teclistamab impairs humoral immunity in patients with heavily pretreated myeloma: importance of immunoglobulin supplementation.. Blood advances. 2024. DOI: 10.1182/bloodadvances.2023011658.

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