A comprehensive review on apoptotic miRNAs and antagomiRs in breast cancer: Enhancing radio sensitization.

Breast cancer (BC) is the most fatal cancer in women worldwide, and in spite of progresses in cancer treatment methods, its therapy has remained as a primary health issue. Inadequate apoptosis level is one of the main reasons of radiotherapy and chemotherapy resistance in lots of cancers including BC. Besides, gene therapy is one of new methods which has been proposed and developed in recent decades for various diseases diagnosis and treatment containing cancer. Since changes in miRs level which are one of different types of RNA molecules have been proved in assorted diseases, they are utilized as a gene therapy agent in order to make influence in diverse signaling pathways which are effective in unappealing biological alteration. In lots of studies, miRs' role in apoptosis pathway in combination with radiotherapy, chemotherapy or solely have been investigated. Many miRNAs and anti-miRNAs have been demonstrated as radiosensitizers/radioresistance agents and chemosensitisers/chemoresistance agents through apoptosis cell death pathways, and numerous miRs have been introduced as apoptotic regulators and they have a good potential to be radiosensitizers and their role in these pathways must be investigated. In the current review, we have tried to investigate and summarize radiosensitizer and radioresistant miRs and anti-microRNAs (anti-miRs) which have been utilized in BC.