Expression and significance of IL-27 and IL-35 in orbital fat in patients with severe TAO.

To detect the expression of Interleukin-27 (IL-27) and Interleukin-35 (IL-35) in orbital fat in patients with severe TAO (thyroid-related eye disease) exophthalmos, and to investigate its potential role and significance in the development of TAO. A study group of 30 patients (30 eyes) who underwent orbital decompression with severe TAO exophthalmos in the Department of Ophthalmology, Provincial Hospital affiliated to Shandong First Medical University from January 2022 to December 2023, the expression of IL-27 and IL-35 of the orbital adipose tissue was detected by western-blot, and which in 30 patients (30 eyes) underwent orbital fracture surgery and plastic repair as control group. The contents of IL-27 and IL-35 were higher in severe TAO patients than in normal controls, and the difference was significant (P < 0.01). IL-27 and IL-35 are significantly increased in the orbital fat of TAO patients with severe protrusion, suggesting that these two cytokines play key roles in the regulation of orbital fat dysplasia and the inflammatory process of TAO, and their expression has certain clinical value in the evaluation of TAO disease.