Blood · 2025
Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mateos-Jaimez Judith, Vidal-Crespo Anna, Charalampopoulou Stella, Pérez Raúl F, Chapaprieta Vicente, Jiménez-Martínez Víctor, Caviedes-Cárdenas Liska, Duran-Ferrer Martí, Espadas Guadalupe, Sabidó Eduard, Largeot Anne, Herbst Sophie A, Dietrich Sascha, Boente Miguel Bastos, Alcoceba Miguel, Nadeu Ferran, Ringshausen Ingo, Paggetti Jerome, Moussay Etienne, Colomer Dolors, Campo Elias, Maiques-Diaz Alba, Martin-Subero Jose I
Аннотация
INTRODUCTION: Whooping cough (pertussis) is an acute respiratory infection primarily caused by Bordetella pertussis, which predominantly affects children. While the disease commonly presents with upper respiratory symptoms, it can lead to severe complications such as pneumonia, encephalopathy, and even death. The association between respiratory infections and renal injury, specifically acute interstitial nephritis (AIN), remains poorly understood. This report describes a rare case of AIN in a patient with whooping cough.
CASE PRESENTATIONS: A 73-year-old male with a history of systemic arterial hypertension, dyslipidemia, and previous left nephrectomy presented with a 5-day history of fatigue, fever, cough, and nasal obstruction. Initial laboratory findings revealed mild leukocytosis and significantly elevated serum creatinine (5.17 mg/dL), with urinalysis showing leukocyturia and proteinuria. A respiratory infection panel confirmed B. pertussis, and the patient was treated with azithromycin. Despite improvement in respiratory symptoms, renal function remained impaired. Renal biopsy revealed moderate tubulointerstitial nephritis, and the patient was treated with prednisone, leading to gradual recovery of renal function, with serum creatinine decreasing to 2.3 mg/dL at discharge and 1.85 mg/dL 3 weeks later.
CONCLUSION: This case highlights the potential renal complications of whooping cough, specifically AIN, a rarely reported association. Although respiratory infections such as pertussis are well known for pulmonary involvement, clinicians should be aware of the possibility of concurrent renal injury. Prompt recognition and appropriate treatment, including corticosteroids in the case of AIN, can lead to significant improvement in renal function. Further research is needed to better understand the mechanisms by which B. pertussis may cause renal damage.
CASE PRESENTATIONS: A 73-year-old male with a history of systemic arterial hypertension, dyslipidemia, and previous left nephrectomy presented with a 5-day history of fatigue, fever, cough, and nasal obstruction. Initial laboratory findings revealed mild leukocytosis and significantly elevated serum creatinine (5.17 mg/dL), with urinalysis showing leukocyturia and proteinuria. A respiratory infection panel confirmed B. pertussis, and the patient was treated with azithromycin. Despite improvement in respiratory symptoms, renal function remained impaired. Renal biopsy revealed moderate tubulointerstitial nephritis, and the patient was treated with prednisone, leading to gradual recovery of renal function, with serum creatinine decreasing to 2.3 mg/dL at discharge and 1.85 mg/dL 3 weeks later.
CONCLUSION: This case highlights the potential renal complications of whooping cough, specifically AIN, a rarely reported association. Although respiratory infections such as pertussis are well known for pulmonary involvement, clinicians should be aware of the possibility of concurrent renal injury. Prompt recognition and appropriate treatment, including corticosteroids in the case of AIN, can lead to significant improvement in renal function. Further research is needed to better understand the mechanisms by which B. pertussis may cause renal damage.