Environmental research · 2026
Different effects of prenatal air pollution exposure on cord blood protein profiles and postnatal lung function in infants born to asthmatic mothers.
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Da Silva Sena Carla Rebeca, Gorlanova Olga, Künstle Noëmi, Costa Gomes Gabriela Martins, Marten Andrea, Schulzke Sven, Wyler Florian, Murphy Vanessa E, Robinson Paul D, Sly Peter D, Usemann Jakob, Stoecklin Benjamin, Yammine Sophie, Latzin Philipp, Sinues Pablo, Gibson Peter G, Karmaus Wilfried J J, Morgan Geoffrey G, Gopi Karthik, de Hoogh Kees, Röösli Martin, Collison Adam M, Mattes Joerg, Frey Urs, BILD and BLT study groups
Аннотация
RATIONALE: Prenatal exposure to air pollution is linked to impaired infant lung function. At-risk infants, such as those born to mothers with asthma during pregnancy, may be more vulnerable.
OBJECTIVES: Investigate whether prenatal particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) exposure is associated with lung function and cord blood proteins in infants of mothers with asthma during pregnancy compared to those of non-asthmatics.
METHODS: In the Swiss Basel-Bern Lung Development and the Australian Breathing for Life Trial cohorts, we investigated associations between prenatal PM2.5 exposure, lung function, and cord blood proteins (n = 433 infants of asthmatic mothers; n = 620 of non-asthmatic mothers).
RESULTS: PM2.5 exposure was inversely associated with functional residual capacity, with stronger reductions among infants of asthmatic mothers (β -0.19 SD, p < 0.001) than those of non-asthmatics (β -0.08 SD, p = 0.059; p for interaction = 0.031). Exposure was associated with increased FeNO in infants of asthmatic mothers (β = 0.12 SD, p = 0.050), but decreased FeNO (β -0.15 SD, p = 0.003) for those of non-asthmatics (p for interaction = 0.001). The association between maternal PM2.5 exposure and cord blood protein levels differed by maternal asthma status. Infants of asthmatic mothers had higher VEGF-A (1.02 SD, p = 0.016), IL-9 (0.44 SD, p = 0.042), IL-10 (0.41 SD, p = 0.048), and IL-13 (0.43 SD, p = 0.046) concentrations than those of non-asthmatics who only had higher TNF-α (0.08 SD, p = 0.041). However, after multiple-comparison correction, these associations did not remain significant.
CONCLUSION: Lung function in infants of mothers with asthma during pregnancy is more affected by PM2.5 compared to those of non-asthmatic mothers. Different PM2.5 association patterns for FeNO and cord blood proteins may indicate different host response mechanisms.
OBJECTIVES: Investigate whether prenatal particulate matter ⩽2.5 μm in aerodynamic diameter (PM2.5) exposure is associated with lung function and cord blood proteins in infants of mothers with asthma during pregnancy compared to those of non-asthmatics.
METHODS: In the Swiss Basel-Bern Lung Development and the Australian Breathing for Life Trial cohorts, we investigated associations between prenatal PM2.5 exposure, lung function, and cord blood proteins (n = 433 infants of asthmatic mothers; n = 620 of non-asthmatic mothers).
RESULTS: PM2.5 exposure was inversely associated with functional residual capacity, with stronger reductions among infants of asthmatic mothers (β -0.19 SD, p < 0.001) than those of non-asthmatics (β -0.08 SD, p = 0.059; p for interaction = 0.031). Exposure was associated with increased FeNO in infants of asthmatic mothers (β = 0.12 SD, p = 0.050), but decreased FeNO (β -0.15 SD, p = 0.003) for those of non-asthmatics (p for interaction = 0.001). The association between maternal PM2.5 exposure and cord blood protein levels differed by maternal asthma status. Infants of asthmatic mothers had higher VEGF-A (1.02 SD, p = 0.016), IL-9 (0.44 SD, p = 0.042), IL-10 (0.41 SD, p = 0.048), and IL-13 (0.43 SD, p = 0.046) concentrations than those of non-asthmatics who only had higher TNF-α (0.08 SD, p = 0.041). However, after multiple-comparison correction, these associations did not remain significant.
CONCLUSION: Lung function in infants of mothers with asthma during pregnancy is more affected by PM2.5 compared to those of non-asthmatic mothers. Different PM2.5 association patterns for FeNO and cord blood proteins may indicate different host response mechanisms.