Urologiia (Moscow, Russia : 1999) · 2025
[Characteristics of the Pathogenic Potential of Staphylococcus aureus Strains Isolated from Prostatic Secretions in Chronic Bacterial Prostatitis].
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Kuzmin M D, Kartashova O L, Kapustina O A, Pashkova T M, Popova L P, Gritsenko V A
Аннотация
AIM: To analyze genes that determine pathogenicity factors in staphylococcal strains isolated from prostatic secretions in chronic bacterial prostatitis.
MATERIALS AND METHODS: Staphylococci were isolated from the prostate secretion of men of reproductive age (20-45 years) with chronic bacterial prostatitis using a conventional bacteriological method. The type of staphylococci was determined by MALDI-TOF mass spectrometry. The virulence genes of staphylococci were determined by PCR and sequencing.
RESULTS: The isolated strains were found to have a wide distribution of genetic determinants of pathogenicity, namely adhesion, colonization, invasion, and immune resistance. It was shown that most genes are associated with evasion of the host immune response during infection, which contributes to the chronic course of bacterial prostatitis.
CONCLUSION: It is advisable to further study the genetic determinants of pathogenicity/virulence of Staphylococcus aureus to assess the severity and duration of chronic bacterial prostatitis.
MATERIALS AND METHODS: Staphylococci were isolated from the prostate secretion of men of reproductive age (20-45 years) with chronic bacterial prostatitis using a conventional bacteriological method. The type of staphylococci was determined by MALDI-TOF mass spectrometry. The virulence genes of staphylococci were determined by PCR and sequencing.
RESULTS: The isolated strains were found to have a wide distribution of genetic determinants of pathogenicity, namely adhesion, colonization, invasion, and immune resistance. It was shown that most genes are associated with evasion of the host immune response during infection, which contributes to the chronic course of bacterial prostatitis.
CONCLUSION: It is advisable to further study the genetic determinants of pathogenicity/virulence of Staphylococcus aureus to assess the severity and duration of chronic bacterial prostatitis.