EJVES vascular forum · 2026
Comparison of a New Halloysite Based Haemostatic Gauze (SpeedM) With a Kaolin Based Gauze (QuikClot Combat Gauze) in a Standardised Lethal Porcine Model of Uncontrolled Haemorrhage.
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Hinck Daniel, Gäth Catharina, Wipper Sabine, Debus Sebastian
Аннотация
INTRODUCTION: The study investigates the effectiveness of a newly developed halloysite coated haemostatic gauze (haemostatic gauze (HG), SpeedM) compared with kaolin coated QuikClot Combat Gauze (CG) in a standardised lethal porcine model of arterial haemorrhage. The study aimed to evaluate halloysite's potential as a novel haemostatic agent for traumatic bleeding treatment.
METHOD: Twenty-one anticoagulated pigs underwent a standardised femoral artery injury under anaesthesia. The animals were randomised to treatment with either HG (n = 10) or CG (n = 11). After a five minute compression at 200 mmHg, haemostatic performance was assessed based on primary haemostasis, need for secondary application, haemodynamic stability, and survival over a sixty minute observation period after returning to baseline.
RESULTS: Both products achieved primary haemostasis under controlled conditions. Secondary application defined as primary failure was needed in 10% of HG (n = 1) and 18% of CG (n = 2) but without fatality. The mortality rate owing to unstoppable bleeding defined as final failure was lower in the HG group (10%, n = 1) than in the CG group (27%, n = 3). One death occurred in each group before a mean arterial pressure ≥60 mmHg was reached. The other two of the three CG fatalities occurred at a mean arterial pressure >60 mmHg.
CONCLUSION: Although no statistically significant differences were observed between HG and CG regarding mortality (p = .59) or re-application rates (p = 1.0), the unique physicochemical properties of halloysite may warrant further investigation in future adequately powered studies.
METHOD: Twenty-one anticoagulated pigs underwent a standardised femoral artery injury under anaesthesia. The animals were randomised to treatment with either HG (n = 10) or CG (n = 11). After a five minute compression at 200 mmHg, haemostatic performance was assessed based on primary haemostasis, need for secondary application, haemodynamic stability, and survival over a sixty minute observation period after returning to baseline.
RESULTS: Both products achieved primary haemostasis under controlled conditions. Secondary application defined as primary failure was needed in 10% of HG (n = 1) and 18% of CG (n = 2) but without fatality. The mortality rate owing to unstoppable bleeding defined as final failure was lower in the HG group (10%, n = 1) than in the CG group (27%, n = 3). One death occurred in each group before a mean arterial pressure ≥60 mmHg was reached. The other two of the three CG fatalities occurred at a mean arterial pressure >60 mmHg.
CONCLUSION: Although no statistically significant differences were observed between HG and CG regarding mortality (p = .59) or re-application rates (p = 1.0), the unique physicochemical properties of halloysite may warrant further investigation in future adequately powered studies.