Clinical Practice Guideline for Spontaneous Isolated Superior Mesenteric Artery Dissection (2025 Edition).

BACKGROUND

Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a relatively rare but potentially life-threatening disease. Optimal medical management strategies remain uncertain. Therefore, developing evidence-based clinical practice guidelines is essential to improve the treatment of SISMAD.

METHODS

The guideline adopted approaches informed by the Grading of Recommendations, Assessment, Development, and Evaluation methodology and the European Society of Cardiology grading system. Recommendations were formulated according to the quality of evidence, categorized as high (level A), moderate (level B), or low (level C).

RESULTS

After reviewing the literature on eight topics, including clinical presentation, imaging evaluation, classification, medical management strategies, and follow-up, the guideline writing committee issued 19 recommendations based on the currently available evidence.

CONCLUSION

Among the 19 recommendations, only a minority were supported by high-quality evidence, underscoring the urgent need for further well-designed clinical studies and prospective research to refine the management of SISMAD.