Sexually transmitted infections · 2026
Combination therapy for multidrug-resistant Mycoplasma genitalium infections: a case series.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vanbaelen Thibaut, Huis In 't Veld Diana, Visser Benjamin J, De Baetselier Irith, Van Praet Jens Tomas, Manoharan-Basil Sheeba Santhini, Van den Bossche Dorien, Kenyon Chris
Аннотация
OBJECTIVES: In Belgium, approximately a quarter of Mycoplasma genitalium infections are resistant to both macrolides and fluoroquinolones-termed multidrug-resistant (MDR) infections. The optimal treatment approach for these MDR infections remains uncertain. Combination therapy has shown promise in treating other MDR pathogens by enhancing efficacy and reducing resistance development. We report the first five cases of MDR M. genitalium urethritis successfully treated with a novel combination therapy regimen consisting of minocycline, metronidazole, methenamine and pristinamycin ('M3P').
METHODS: We describe a case series of five individuals treated with M3P as salvage therapy for M. genitalium urethritis. Clinical data, laboratory findings, resistance profiles and treatment outcomes were reviewed.
RESULTS: All five men with macrolide-resistant and fluoroquinolone-resistant M. genitalium urethritis received M3P for a minimum of 14 days. Two men received an extended 28-day M3P regimen, in which minocycline and methenamine were given for 28 days. All five patients experienced clinical and microbiological cure. Adverse effects were minimal and transient, with one patient reporting increased urinary frequency during treatment and another reporting mild dyspepsia.
CONCLUSIONS: This case series demonstrates the potential efficacy of M3P as a novel salvage therapy for MDR M. genitalium urethritis, particularly where standard therapies have failed. The combination of pristinamycin, methenamine, and other agents may synergistically reduce bacterial load and increase efficacy. Further, in vitro and clinical studies are required to assess the optimal treatment strategies for MDR M. genitalium.
METHODS: We describe a case series of five individuals treated with M3P as salvage therapy for M. genitalium urethritis. Clinical data, laboratory findings, resistance profiles and treatment outcomes were reviewed.
RESULTS: All five men with macrolide-resistant and fluoroquinolone-resistant M. genitalium urethritis received M3P for a minimum of 14 days. Two men received an extended 28-day M3P regimen, in which minocycline and methenamine were given for 28 days. All five patients experienced clinical and microbiological cure. Adverse effects were minimal and transient, with one patient reporting increased urinary frequency during treatment and another reporting mild dyspepsia.
CONCLUSIONS: This case series demonstrates the potential efficacy of M3P as a novel salvage therapy for MDR M. genitalium urethritis, particularly where standard therapies have failed. The combination of pristinamycin, methenamine, and other agents may synergistically reduce bacterial load and increase efficacy. Further, in vitro and clinical studies are required to assess the optimal treatment strategies for MDR M. genitalium.