Journal of pharmacy & bioallied sciences · 2025
Ceruloplasmin as a Vital Tool for Grading of Preeclampsia: A Case-Control Study in Central India.
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Raghuwanshi Kapil, Narrey Nidhi, Dandotiya Dileep, Tambade Swapnali, Gandhe Mahendra, Sharma Ranjana
Аннотация
BACKGROUND: Preeclampsia (PE) is a hypertensive disorder of pregnancy, characterized by high blood pressure (≥ 140/90 mmHg), proteinuria, and edema after 20 weeks of gestation. Affecting 3-10% of pregnancies globally, PE is a leading cause of maternal and fetal morbidity and mortality.
MATERIALS AND METHODS: This case-control study involved 105 pregnant women in their third trimester (28-40 weeks), divided into three groups: 35 normotensive controls, 35 with mild preeclampsia, and 35 with severe preeclampsia. Serum ceruloplasmin levels were measured using a turbidimetry method on a Biosystem BA400 analyzer. Statistical analysis was performed using SPSS software, with P values < 0.05 considered statistically significant.
RESULTS: The study found significantly higher ceruloplasmin levels in preeclamptic women compared to the control group. Normotensive women had mean ceruloplasmin levels of 84.53 ± 7.33 mg/dl, while women with mild and severe preeclampsia had levels of 107.44 ± 7.37 mg/dl and 135.42 ± 10.73 mg/dl, respectively. The differences were statistically significant (P < 0.00001).
CONCLUSION: Elevated serum ceruloplasmin levels were strongly associated with the severity of preeclampsia. Early detection of elevated levels may help in diagnosing and managing preeclampsia, potentially reducing maternal and fetal complications.
MATERIALS AND METHODS: This case-control study involved 105 pregnant women in their third trimester (28-40 weeks), divided into three groups: 35 normotensive controls, 35 with mild preeclampsia, and 35 with severe preeclampsia. Serum ceruloplasmin levels were measured using a turbidimetry method on a Biosystem BA400 analyzer. Statistical analysis was performed using SPSS software, with P values < 0.05 considered statistically significant.
RESULTS: The study found significantly higher ceruloplasmin levels in preeclamptic women compared to the control group. Normotensive women had mean ceruloplasmin levels of 84.53 ± 7.33 mg/dl, while women with mild and severe preeclampsia had levels of 107.44 ± 7.37 mg/dl and 135.42 ± 10.73 mg/dl, respectively. The differences were statistically significant (P < 0.00001).
CONCLUSION: Elevated serum ceruloplasmin levels were strongly associated with the severity of preeclampsia. Early detection of elevated levels may help in diagnosing and managing preeclampsia, potentially reducing maternal and fetal complications.