JACC. Case reports · 2026
Gestational Trophoblastic Neoplasia With Intracardiac Metastatic Masses.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Zarate-Correa Luz Clemencia, Bejarano-Oliveros María Camila, Reyes-Cardona María Juliana, Vesga-Reyes Carlos Enrique, Olaya Pastor, Zambrano-Franco Jorge Alexander, Sánchez-Blanco Jairo, Calderón-Miranda Camilo Andrés
Аннотация
BACKGROUND: Gestational trophoblastic neoplasia (GTN) with cardiac involvement is exceedingly rare and may mimic thrombus or primary cardiac tumor, complicating diagnosis.
CASE SUMMARY: A 28-year-old woman with a history of complete hydatidiform mole presented with acute cardiopulmonary symptoms, abdominal pain, and markedly elevated β-human chorionic gonadotropin (β-hCG) levels. Multimodality imaging revealed mobile left-sided intracardiac masses with pulmonary vein extension and metastatic renal lesions. Stage IV high-risk GTN was diagnosed without tissue biopsy, and multiagent chemotherapy was initiated, resulting in sustained β-hCG normalization and near-complete resolution of intracardiac masses on follow-up imaging.
DISCUSSION: This case highlights the diagnostic challenges of cardiac involvement in GTN and underscores the importance of multimodality imaging in differentiating metastases from thrombus, enabling prompt initiation of life-saving systemic therapy.
TAKE-HOME MESSAGES: GTN should be considered in patients with markedly elevated β-hCG and unexplained intracardiac masses. Multimodality imaging is essential to guide timely and appropriate diagnosis and management.
CASE SUMMARY: A 28-year-old woman with a history of complete hydatidiform mole presented with acute cardiopulmonary symptoms, abdominal pain, and markedly elevated β-human chorionic gonadotropin (β-hCG) levels. Multimodality imaging revealed mobile left-sided intracardiac masses with pulmonary vein extension and metastatic renal lesions. Stage IV high-risk GTN was diagnosed without tissue biopsy, and multiagent chemotherapy was initiated, resulting in sustained β-hCG normalization and near-complete resolution of intracardiac masses on follow-up imaging.
DISCUSSION: This case highlights the diagnostic challenges of cardiac involvement in GTN and underscores the importance of multimodality imaging in differentiating metastases from thrombus, enabling prompt initiation of life-saving systemic therapy.
TAKE-HOME MESSAGES: GTN should be considered in patients with markedly elevated β-hCG and unexplained intracardiac masses. Multimodality imaging is essential to guide timely and appropriate diagnosis and management.