Targeting ferroptosis halts graft deterioration in transplantation.

Ischemia-reperfusion injury accelerates graft deterioration and limits the use of marginal donor organs. Recently, Veeckmans et al. showed that pharmacological ferroptosis inhibition preserves liver and lung graft function across porcine and human perfusion platforms, positioning lipid peroxidation-driven cell death as an actionable target in machine perfusion-era transplantation.