[Approach to the diagnosis of patients with febrile rash].

The patient with febrile rash poses a real diagnostic challenge to primary care physician. We report an original case of febrile macular rash whose etiology was related to sepsis secondary to pelviperitonitis and acute cholecystitis. Patient's history, careful physical examination, paraclinical examinations and favorable outcome allowed to retain the infectious origin of the rash, without microbiological confirmation in our study. The skin is an excellent marker for infection. Cutaneous manifestations are the most common signs observed in patients with sepsis at an early stage. Exanthema is the most common lesion; it is due to systemic effects of a microorganism infecting the skin. If there are no clinical signs of infection, early diagnosis can prevent complications.