American journal of translational research · 2025
Added administration of estradiol valerate tosurgical treatment for missed abortion in early pregnancy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Feng Zhiquan, Zhang Yiyun
Аннотация
OBJECTIVE: To explore the clinical effect of different surgical methods for missed abortion in early pregnancy.
METHODS: In this retrospective study 100 patients diagnosed with early missed abortion were assigned to two groups based on the treatment modality. The operation group (n=50) underwent dilatation and curettage (D&C), while the combination group (n=50) received oral estradiol valerate prior to D&C. Clinical outcomes were compared between the two groups, including operative indexes, postoperative adverse events, cervical dilation effect, abortion outcomes, estrogen levels, endometria-related indexes, inflammatory markers, and levels of pregnancy associated protein A (PAPP-A).
RESULTS: Compared to the operation group, the combination group showed significantly reduced intraoperative blood loss, shorter durations of vaginal bleeding and operation time, greater postoperative endometrial thickness, and a lower incidence of postoperative intrauterine adhesions and total adverse events (all P<0.05). The total effective rate (χ2=4.320) and total abortion rate (Z=-3.525; χ2=5.020) were also significantly higher in the combination group. Moreover, the combination group exhibited higher postoperative levels of estradiol (E2), progesterone (P), β-human chorionic gonadotropin (β-hCG), and follicle-stimulating hormone (FSH), while levels of luteinizing hormone (LH), P, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and PAPP-A were lower (all P<0.05).
CONCLUSION: Oral administration of estradiol valerate followed by D&C demonstrates superior clinical efficacy in the management of missed abortion during early pregnancy. This can enhance cervical dilation, facilitate abortion, modulate estrogen levels, promote endometrial repair, and relieve inflammation.
METHODS: In this retrospective study 100 patients diagnosed with early missed abortion were assigned to two groups based on the treatment modality. The operation group (n=50) underwent dilatation and curettage (D&C), while the combination group (n=50) received oral estradiol valerate prior to D&C. Clinical outcomes were compared between the two groups, including operative indexes, postoperative adverse events, cervical dilation effect, abortion outcomes, estrogen levels, endometria-related indexes, inflammatory markers, and levels of pregnancy associated protein A (PAPP-A).
RESULTS: Compared to the operation group, the combination group showed significantly reduced intraoperative blood loss, shorter durations of vaginal bleeding and operation time, greater postoperative endometrial thickness, and a lower incidence of postoperative intrauterine adhesions and total adverse events (all P<0.05). The total effective rate (χ2=4.320) and total abortion rate (Z=-3.525; χ2=5.020) were also significantly higher in the combination group. Moreover, the combination group exhibited higher postoperative levels of estradiol (E2), progesterone (P), β-human chorionic gonadotropin (β-hCG), and follicle-stimulating hormone (FSH), while levels of luteinizing hormone (LH), P, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and PAPP-A were lower (all P<0.05).
CONCLUSION: Oral administration of estradiol valerate followed by D&C demonstrates superior clinical efficacy in the management of missed abortion during early pregnancy. This can enhance cervical dilation, facilitate abortion, modulate estrogen levels, promote endometrial repair, and relieve inflammation.