Added administration of estradiol valerate tosurgical treatment for missed abortion in early pregnancy.

OBJECTIVE

To explore the clinical effect of different surgical methods for missed abortion in early pregnancy.

METHODS

In this retrospective study 100 patients diagnosed with early missed abortion were assigned to two groups based on the treatment modality. The operation group (n=50) underwent dilatation and curettage (D&C), while the combination group (n=50) received oral estradiol valerate prior to D&C. Clinical outcomes were compared between the two groups, including operative indexes, postoperative adverse events, cervical dilation effect, abortion outcomes, estrogen levels, endometria-related indexes, inflammatory markers, and levels of pregnancy associated protein A (PAPP-A).

RESULTS

Compared to the operation group, the combination group showed significantly reduced intraoperative blood loss, shorter durations of vaginal bleeding and operation time, greater postoperative endometrial thickness, and a lower incidence of postoperative intrauterine adhesions and total adverse events (all P<0.05). The total effective rate (χ2=4.320) and total abortion rate (Z=-3.525; χ2=5.020) were also significantly higher in the combination group. Moreover, the combination group exhibited higher postoperative levels of estradiol (E2), progesterone (P), β-human chorionic gonadotropin (β-hCG), and follicle-stimulating hormone (FSH), while levels of luteinizing hormone (LH), P, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and PAPP-A were lower (all P<0.05).

CONCLUSION

Oral administration of estradiol valerate followed by D&C demonstrates superior clinical efficacy in the management of missed abortion during early pregnancy. This can enhance cervical dilation, facilitate abortion, modulate estrogen levels, promote endometrial repair, and relieve inflammation.