Intracranial Venous Sinus Thrombosis and Peripheral Venous Thrombosis Following Traumatic Brain Injury and Surgery.

Cerebral venous sinus thrombosis (CVST) is an uncommon cause of stroke. This case report describes a 47-year-old man who developed concurrent sigmoid sinus thrombosis and bilateral cephalic vein thrombosis following traumatic brain injury and surgical evacuation of an epidural hematoma. The patient presented with a new headache on postoperative day 5. Diagnosis was confirmed by CT angiography and Doppler ultrasound. He was successfully treated with subcutaneous enoxaparin, resulting in symptom resolution and radiologic improvement. This case highlights that CVST can co-occur with peripheral thrombosis post-trauma, indicating a systemic hypercoagulable state. Early recognition and anticoagulation are crucial for management, even in a postoperative setting, underscoring the need for vigilance in these complex patients.