Hormone molecular biology and clinical investigation · 2025
WNT5A in ovarian physiology and pathology: from molecular mechanisms to therapeutic potential.
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Gao Qing, Fu Jiang
Аннотация
INTRODUCTION: As a pivotal molecule in tissue development and homeostasis, WNT5A regulates various aspects of ovarian physiology, including folliculogenesis, oocyte maturation, and hormonal responses.
CONTENT: This review summarizes current knowledge on the molecular mechanisms of WNT5A signaling, its role in ovarian health, and its pathological involvement in disorders such as polycystic ovary syndrome (PCOS) and ovarian cancer. We discuss how WNT5A may be a double-edged sword in ovarian diseases and explore its therapeutic potential.
SUMMARY: In PCOS, WNT5A exacerbates the inflammatory environment and insulin resistance, disrupting normal folliculogenesis and leading to impaired ovarian function. Moreover, in ovarian cancer, WNT5A presents challenges for therapeutic targeting, as it can either inhibit or facilitate tumor progression depending on the context.
OUTLOOK: Continued research into the peripheral and central regulatory mechanisms of WNT5A, along with its interactions with other signaling pathways, will be instrumental in unlocking its full therapeutic potential.
CONTENT: This review summarizes current knowledge on the molecular mechanisms of WNT5A signaling, its role in ovarian health, and its pathological involvement in disorders such as polycystic ovary syndrome (PCOS) and ovarian cancer. We discuss how WNT5A may be a double-edged sword in ovarian diseases and explore its therapeutic potential.
SUMMARY: In PCOS, WNT5A exacerbates the inflammatory environment and insulin resistance, disrupting normal folliculogenesis and leading to impaired ovarian function. Moreover, in ovarian cancer, WNT5A presents challenges for therapeutic targeting, as it can either inhibit or facilitate tumor progression depending on the context.
OUTLOOK: Continued research into the peripheral and central regulatory mechanisms of WNT5A, along with its interactions with other signaling pathways, will be instrumental in unlocking its full therapeutic potential.