European journal of obstetrics, gynecology, and reproductive biology · 2026
Association between sleep disorders during pregnancy and hypertensive disorders of pregnancy: A systematic review and meta-analysis of cohort studies.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Guo Si-Jie, Xu Jia-Shuang, Cai Jie, Gao Hong-Feng, Wei Li-Qing
Аннотация
BACKGROUND: Sleep disorders during pregnancy have been increasingly recognized as potential risk factors for adverse maternal outcomes. However, the association between different types of sleep disorders and hypertensive disorders during pregnancy remains inconsistent across cohort studies. We conducted a systematic review and meta-analysis of cohort studies to evaluate the association between sleep disorders during pregnancy and the risk of gestational hypertension (GH), preeclampsia (PE), and hypertensive disorders of pregnancy (HDP).
METHODS: A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted from the inception of the databases through April 3, 2026. Cohort studies investigating the association between sleep disorders during pregnancy and GH, PE, or HDP were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effects models according to heterogeneity. Subgroup analyses were conducted based on the type of sleep disorder.
RESULTS: A total of 19 cohort studies involving 9,460,018 pregnant women from multiple countries were included. Overall, sleep disorders during pregnancy were significantly associated with increased risks of GH (OR = 1.50, 95% CI: 1.23-1.82), PE (OR = 1.83, 95% CI: 1.53-2.18), and HDP (OR = 1.56, 95% CI: 1.17-2.08). Subgroup analyses demonstrated that obstructive sleep apnea (OSA) showed the strongest and most consistent associations with hypertensive outcomes, including GH (OR = 1.60, 95% CI: 1.45-1.78) and PE (OR = 2.13, 95% CI: 1.97-2.30). Mid-pregnancy sleep-disordered breathing characterized by increased apnea-hypopnea index (AHI) was associated with significantly increased risks of HDP and PE, whereas early-pregnancy increased AHI was not significantly associated with these outcomes. Snoring was associated with elevated risks of PE and HDP, while insomnia and poor sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) were not significantly associated with hypertensive outcomes.
CONCLUSIONS: Sleep disorders during pregnancy are closely associated with a increased risk of GH, PE, and HDP, particularly among women with obstructive sleep apnea or other forms of sleep-disordered breathing. These findings underscore the importance of maternal sleep health as a modifiable risk factor during pregnancy. Early identification of sleep disorders may facilitate risk stratification and further evaluation in pregnant women.
METHODS: A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted from the inception of the databases through April 3, 2026. Cohort studies investigating the association between sleep disorders during pregnancy and GH, PE, or HDP were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effects models according to heterogeneity. Subgroup analyses were conducted based on the type of sleep disorder.
RESULTS: A total of 19 cohort studies involving 9,460,018 pregnant women from multiple countries were included. Overall, sleep disorders during pregnancy were significantly associated with increased risks of GH (OR = 1.50, 95% CI: 1.23-1.82), PE (OR = 1.83, 95% CI: 1.53-2.18), and HDP (OR = 1.56, 95% CI: 1.17-2.08). Subgroup analyses demonstrated that obstructive sleep apnea (OSA) showed the strongest and most consistent associations with hypertensive outcomes, including GH (OR = 1.60, 95% CI: 1.45-1.78) and PE (OR = 2.13, 95% CI: 1.97-2.30). Mid-pregnancy sleep-disordered breathing characterized by increased apnea-hypopnea index (AHI) was associated with significantly increased risks of HDP and PE, whereas early-pregnancy increased AHI was not significantly associated with these outcomes. Snoring was associated with elevated risks of PE and HDP, while insomnia and poor sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI) were not significantly associated with hypertensive outcomes.
CONCLUSIONS: Sleep disorders during pregnancy are closely associated with a increased risk of GH, PE, and HDP, particularly among women with obstructive sleep apnea or other forms of sleep-disordered breathing. These findings underscore the importance of maternal sleep health as a modifiable risk factor during pregnancy. Early identification of sleep disorders may facilitate risk stratification and further evaluation in pregnant women.