Reproductive toxicology (Elmsford, N.Y.) · 2015
Medications as a source of paraben exposure.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Dodge Laura E, Kelley Katherine E, Williams Paige L, Williams Michelle A, Hernández-Díaz Sonia, Missmer Stacey A, Hauser Russ
Аннотация
BACKGROUND: Parabens are used as antimicrobial excipients in some pharmaceuticals. Parabens may adversely affect reproduction.
OBJECTIVES: Determine whether paraben-containing medication contributes to high urinary paraben concentrations.
METHODS: Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples "exposed" and "unexposed" to paraben-containing medication.
RESULTS: Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7h was associated with 8.7-fold and 7.5-fold increases in mean methyl (P=0.11) and propyl (P=0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P=0.76) and 2.6-fold (P=0.34), respectively, after removal of one influential individual.
CONCLUSION: Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.
OBJECTIVES: Determine whether paraben-containing medication contributes to high urinary paraben concentrations.
METHODS: Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples "exposed" and "unexposed" to paraben-containing medication.
RESULTS: Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7h was associated with 8.7-fold and 7.5-fold increases in mean methyl (P=0.11) and propyl (P=0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P=0.76) and 2.6-fold (P=0.34), respectively, after removal of one influential individual.
CONCLUSION: Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.