Correlation between insulin resistance-related index and recurrent spontaneous abortion: a retrospective study.

OBJECTIVE

To investigate the changes and clinical significance of uterine artery blood flow parameters, insulin resistance index, and the triglyceride-glucose (TyG) index in patients with recurrent spontaneous abortion (RSA).

METHODS

A total of 72 pregnant women with a history of recurrent spontaneous abortion were enrolled as the RSA group, and 82 pregnant women without a history of abnormal pregnancy during the same period were selected as the normal pregnancy group. Fasting insulin (FINS), fasting blood glucose (FBG), insulin resistance index (HOMA-IR), uterine artery pulsatility index (PI), resistance index (RI), the ratio of uterine artery systolic maximum blood flow velocity to end-diastolic blood flow velocity (S/D) and TyG index were compared between the two groups at 6-10 weeks of gestation. Multivariate analysis was performed to identify independent risk factors for RSA. Receiver operating characteristic (ROC) curves were used to evaluate the predictive performance of individual and combined indicators.

RESULTS

There were significant differences in age, FINS, HOMA-IR, uterine artery PI and RI, S/D ratio, and TyG index between the RSA group and the control group (all P < 0.05). Multivariate analysis identified these variables as independent risk factors for RSA. The combined predictive model yielded an AUC of 0.881.

CONCLUSION

There is a direct correlation between the insulin resistance and the occurrence of recurrent spontaneous abortion. A combination of multiple metabolic and hemodynamic parameters may improve the predictive accuracy for RSA.