Relationship of smoking status to genomic profile, chemotherapy response and clinical outcome in patients with advanced urothelial carcinoma.

Carpal instability includes a broad spectrum of osseous and ligamentous injuries which have been subclassified into greater and lesser arc injuries, in addition to combinations of both (Mayfield et al. J Hand Surg [Am] 5:226-241, 1980; Yaeger et al. Skeletal Radiol 13(2):120-30, 1985). The injuries typically occur from a fall on the outstretched hand with the wrist in ulnar deviation, hyperextension, and intercarpal supination (Yaeger et al. Skeletal Radiol 13(2):120-30, 1985). The force classically propagates from the radial to the ulnar side of the wrist resulting in a fracture (greater arc) or dislocation (lesser arc) pattern with the extent of the injury occurring in an orderly pattern depending upon the degree of hyperextension and the duration and magnitude of the force (Mayfield et al. J Hand Surg [Am] 5:226-241, 1980; Yaeger et al. Skeletal Radiol 13(2):120-30, 1985). Multiple variations occur, including transradial styloid fractures as well as fractures through carpal bones surrounding the lunate (Mayfield et al. J Hand Surg [Am] 5:226-241, 1980; Yaeger et al. Skeletal Radiol 13(2):120-30, 1985; Kozin SH. J Am Acad Orthop Surg 6 (2): 114-20, 1998. Although carpal dislocations have been noted for many years, the mechanisms and classification have only been recently clarified. We report a case of a complex dislocation involving the entire proximal carpal row without an associated fracture. While this type of complex carpal dislocation has been previously described, to our knowledge, it has never been reported without a fracture of the forearm, wrist, or hand.