Does Corpus Luteum Doppler Have a Role in Prognostic Prediction for Outcome with Threatened Abortion?

Background/

Objectives

This study evaluated the prognostic value of corpus luteum Doppler findings in predicting pregnancy outcomes in patients with threatened abortion, with or without subchorionic hemorrhage.

Methods

A prospective cohort study included 180 pregnant women diagnosed with threatened abortion in the first trimester-120 without subchorionic hemorrhage and 60 with subchorionic hemorrhage. Corpus luteum Doppler parameters, including systole/diastole ratio, Resistance Index, and Pulsatility Index, were measured via transvaginal ultrasonography. Pregnancy outcomes were categorized as first-trimester abortion or continuation into the second trimester.

Results

Corpus luteum Doppler parameters were significantly higher in patients with first-trimester abortion compared to those with ongoing pregnancies (p < 0.001). Among patients with subchorionic hemorrhage, those who experienced abortion also showed higher Doppler values (p < 0.001). ROC analysis indicated that corpus luteum Doppler parameters effectively predicted first-trimester abortion, with a systole/diastole ratio > 2.87 achieving 77% sensitivity and 75% specificity (AUC = 0.767, p < 0.001).

Conclusions

Corpus luteum Doppler is a valuable, non-invasive tool for predicting pregnancy outcomes in threatened abortion, particularly with subchorionic hemorrhage. Increased resistance in Doppler parameters may indicate luteal insufficiency and reduced progesterone levels. Larger studies are needed to confirm these findings and explore underlying mechanisms.