Respiratory medicine · 2026
Association between urinary metabolites of volatile organic compounds and lung function: A cross-sectional study.
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Chen Jian, Li Yan, Han Zhenzong, Liu Jixiang, Hou Lin
Аннотация
BACKGROUND: Volatile organic compounds (VOCs), play a major role in exacerbating air pollution and present a threat to human health. However, the association between specific VOCs and lung function in the general population has not been extensively explored.
OBJECTIVES: Our study aimed to examine the correlation between urinary VOC metabolites (mVOCs) concentrations and lung function, among a typical sample of the adult population.
METHODS: The correlation between urinary mVOCs and lung function was analyzed using logistic regression models, QG-C, WQS, and BKMR models were employed.
RESULTS: Our study revealed that higher concentrations of certain urinary mVOCs significantly correlated with an increased risk of abnormal lung function, especially URXAMC and URXDHB. A significant nonlinear correlation was observed between URXDHB and FEV1 % pred <80 % (P for overall <0.001, P for nonlinear <0.001), and a nonlinear correlation was noted between URXAMC and the incidence of FEV1 % pred <80 % (P for overall, P for nonlinear = 0.012).
CONCLUSION: VOCs exposure is associated with compromised lung health, and particularly strong correlations exist between URXAMC/URXDHB and abnormal lung function; These findings provide new insights for respiratory disease prevention and control.
OBJECTIVES: Our study aimed to examine the correlation between urinary VOC metabolites (mVOCs) concentrations and lung function, among a typical sample of the adult population.
METHODS: The correlation between urinary mVOCs and lung function was analyzed using logistic regression models, QG-C, WQS, and BKMR models were employed.
RESULTS: Our study revealed that higher concentrations of certain urinary mVOCs significantly correlated with an increased risk of abnormal lung function, especially URXAMC and URXDHB. A significant nonlinear correlation was observed between URXDHB and FEV1 % pred <80 % (P for overall <0.001, P for nonlinear <0.001), and a nonlinear correlation was noted between URXAMC and the incidence of FEV1 % pred <80 % (P for overall, P for nonlinear = 0.012).
CONCLUSION: VOCs exposure is associated with compromised lung health, and particularly strong correlations exist between URXAMC/URXDHB and abnormal lung function; These findings provide new insights for respiratory disease prevention and control.