Association of immunonutrition-based indices (Hemoglobin-Albumin-Lymphocyte-Platelet, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte) with the latency period in preterm prelabor rupture of membranes.

OBJECTIVE

The aim of this study was to evaluate the predictive value of immunonutrition-based indices (Hemoglobin, Albumin, Lymphocyte, Platelet score, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte index) for latency duration and neonatal outcomes in preterm prelabor rupture of membranes.

METHODS

This retrospective cohort study included 145 singleton pregnancies diagnosed with PPROM between 24 and 34 weeks. Patients were categorized by latency duration (≤48 vs. >48 h), and subgroup analyses used thresholds of 72 h, 96 h, and 7 days. Maternal, laboratory, and neonatal characteristics were compared. Logistic regression adjusted for parity and gestational age evaluated associations between indices and latency.

RESULTS

Hemoglobin, Albumin, Lymphocyte, Platelet, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte values showed no significant differences across latency groups (all p>0.05). Only respiratory distress syndrome was more frequent in the short-latency group (p=0.005).

CONCLUSION

Immunonutrition indices remained stable across latency durations, highlighting the predominance of localized inflammatory and structural mechanisms in preterm prelabor rupture of membranes pathophysiology.